About Me


Welcome,


Myself Biren Ghodasara, I have more than 10 years experience in pharmaceutical industry in different area like Pharmaceutical industry Quality control Quality assurance, local pharmacy, Marketing chain.


Objective of creating the blog to the guide Quality control against compliance and productivity. 


This blog open discussion forum for the different topic to the pharmaceutical industry directly and indirectly related to the Quality Control.

Popular posts from this blog

What is Retention time?

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Retention time (RT) is a measure of the time taken for a solute to pass through a chromatography column. Retention time (RT) is calculated as the time from injection to detection. The RT for a compound is not fixed as many factors can influence it even if the same instrument and column are used.  These include: The flow rate Temperature differences in the oven and column Column degradation Column length What is RRT?
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Relation between Resolution and Peak separation?

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The resolution is represented as a numeric value, such as 0.8, 1.0, or 3.0. But what is the relationship between the number representing the resolution and the actual peak separation?  At a resolution of 1.0, if the two peaks are assumed to have a Gaussian distribution and have the same peak height and peak width, then the difference in retention time from equation  become 1.0W, or 1.0 × 4σ = 4 σ.  In the case of a Gaussian distribution, 4 σ encompasses 95.4 %, such that the peaks overlap by 2.3 % ((100 % - 95.4 %)/2).  This indicates that 2.3 % of the peak intrudes into the other peak from a perpendicular line drawn in the trough.  Similarly, a resolution of 1.5 indicates a difference in retention time of 1.5× 4σ = 6σ, which corresponds to an overlap of 0.15 % ((100 % - 99.7 %)/2).
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What is RRT?

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Relative retention time (RRT) is the ratio of the retention time of analyte peak relative to that of another used as a reference obtained under identical conditions. RRT = (T analyte / T reference)  Wher T = Retention time As per USP Relative retention time (RRT): Also known as the “unadjusted relative retention”. Comparisons in USP–NF are normally made in terms of unadjusted relative retention, unless otherwise indicated. RRT = tR2/tR1 The symbol rG is also used to designate unadjusted relative retention values. The use of the relative retention time (RRT) reduces the effects of some of the variables that can affect the retention time. What is Retention time?
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